A Biomarker to Differentiate between Primary and Cocaine-Induced Major Depression in Cocaine Use Disorder: The Role of Platelet IRAS/Nischarin (I1-Imidazoline Receptor)

A Biomarker to Differentiate between Primary and Cocaine-Induced Major Depression in Cocaine Use Disorder: The Role of Platelet IRAS/Nischarin (I1-Imidazoline Receptor)

The association of cocaine use disorder (CUD) and comorbid major depressive disorder (MDD; CUD/MDD) is characterized by high prevalence and poor treatment outcomes. CUD/MDD may be primary (primary MDD) or cocaine-induced (CUD-induced MDD). Specific biomarkers are needed to improve diagnoses and ther...

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Bibliographic Details
Main Authors: Benjamin Keller, Joan-Ignasi Mestre-Pinto, María Álvaro-Bartolomé, Diana Martinez-Sanvisens, Magí Farre, M. Julia García-Fuster, Jesús A. García-Sevilla, Marta Torrens, The NEURODEP Group, F. Fonseca, J. Mateus, E. Papaseit, C. Pérez-Mañá, R. Rodríguez-Minguela, P. Rossi, C. Tamarit, G. Vallecillo
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Psychiatry
Subjects:
platelet biomarker
IRAS/nischarin
cocaine use disorder
major depressive disorder
cocaine-induced depression
acute tryptophan depletion
Online Access:http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00258/full

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http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00258/full

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