Evolution of extreme resistance to ionizing radiation via genetic adaptation of DNA repair

Evolution of extreme resistance to ionizing radiation via genetic adaptation of DNA repair

By directed evolution in the laboratory, we previously generated populations of Escherichia coli that exhibit a complex new phenotype, extreme resistance to ionizing radiation (IR). The molecular basis of this extremophile phenotype, involving strain isolates with a 3-4 order of magnitude increase i...

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Bibliographic Details
Main Authors: Rose T Byrne, Audrey J Klingele, Eric L Cabot, Wendy S Schackwitz, Jeffrey A Martin, Joel Martin, Zhong Wang, Elizabeth A Wood, Christa Pennacchio, Len A Pennacchio, Nicole T Perna, John R Battista, Michael M Cox
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-03-01
Series:eLife
Subjects:
DNA repair
ionizing radiation
evolution
extremophile
mutation
Online Access:https://elifesciences.org/articles/01322

Internet

https://elifesciences.org/articles/01322

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