Beta-adrenergic activation induces cardiac collapse by aggravating cardiomyocyte contractile dysfunction in bupivacaine intoxication.

Beta-adrenergic activation induces cardiac collapse by aggravating cardiomyocyte contractile dysfunction in bupivacaine intoxication.

In order to determine the role of the adrenergic system in bupivacaine-induced cardiotoxicity, a series of experiments were performed. In an animal experiment, male Sprague-Dawley (SD) rats under chloral hydrate anesthesia received intravenous bupivacaine, followed by an intravenous injection of adr...

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Bibliographic Details
Main Authors: Jun Li, Ran Duan, Yingying Zhang, Xin Zhao, Yanxin Cheng, Yongxue Chen, Jinge Yuan, Hong Li, Jianping Zhang, Li Chu, Dengyun Xia, Senming Zhao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6166930?pdf=render

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http://europepmc.org/articles/PMC6166930?pdf=render

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