Cocaine promotes oxidative stress and microglial-macrophage activation in rat cerebellum

Cocaine promotes oxidative stress and microglial-macrophage activation in rat cerebellum

Different mechanisms have been suggested for cocaine neurotoxicity, including oxidative stress alterations. Nuclear factor kappa B (NF-κB), considered a sensor of oxidative stress and inflammation, is involved in drug toxicity and addiction. NF-κB is a key mediator for immune responses that induces...

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Bibliographic Details
Main Authors: Rosa M López-Pedrajas, Dolores Tania Ramirez Lamelas, Borja eMuriach, Maria V Sánchez-Villarejo, Inmaculada eAlmansa, Lorena eVidal-Gil, Francisco Javier Romero, Jorge M Barcia, Maria eMuriach
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Cerebellum
Cocaine
Macrophages
Microglia
Oxidative Stress
nuclear factor kappa B
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00279/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00279/full

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