Inhibition of Acetylcholinesterase Modulates NMDA Receptor Antagonist Mediated Alterations in the Developing Brain

Inhibition of Acetylcholinesterase Modulates NMDA Receptor Antagonist Mediated Alterations in the Developing Brain

Exposure to N-methyl-d-aspartate (NMDA) receptor antagonists has been demonstrated to induce neurodegeneration in newborn rats. However, in clinical practice the use of NMDA receptor antagonists as anesthetics and sedatives cannot always be avoided. The present study investigated the effect of the i...

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Bibliographic Details
Main Authors: Ivo Bendix, Meray Serdar, Josephine Herz, Clarissa von Haefen, Fatme Nasser, Benjamin Rohrer, Stefanie Endesfelder, Ursula Felderhoff-Mueser, Claudia D. Spies, Marco Sifringer
Format: Article
Language:English
Published: MDPI AG 2014-03-01
Series:International Journal of Molecular Sciences
Subjects:
developing brain
NMDA receptor
MK801
acetylcholinesterase
extracellular matrix
BDNF
neuroprotection
Online Access:http://www.mdpi.com/1422-0067/15/3/3784

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http://www.mdpi.com/1422-0067/15/3/3784

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