Functional Characterization of the Dopaminergic Psychostimulant Sydnocarb as an Allosteric Modulator of the Human Dopamine Transporter

Functional Characterization of the Dopaminergic Psychostimulant Sydnocarb as an Allosteric Modulator of the Human Dopamine Transporter

The dopamine transporter (DAT) serves a critical role in controlling dopamine (DA)-mediated neurotransmission by regulating the clearance of DA from the synapse and extrasynaptic regions and thereby modulating DA action at postsynaptic DA receptors. Major drugs of abuse such as amphetamine and cocai...

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Bibliographic Details
Main Authors: Shaili Aggarwal, Mary Hongying Cheng, Joseph M. Salvino, Ivet Bahar, Ole Valente Mortensen
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Biomedicines
Subjects:
dopamine transporter
allosteric modulation
transport activity
Online Access:https://www.mdpi.com/2227-9059/9/6/634

Internet

https://www.mdpi.com/2227-9059/9/6/634

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