mTOR signaling is activated by FLT3 kinase and promotes survival of <it>FLT3-</it>mutated acute myeloid leukemia cells

mTOR signaling is activated by FLT3 kinase and promotes survival of <it>FLT3-</it>mutated acute myeloid leukemia cells

<p>Abstract</p> <p>Activating mutations of the <it>FLT3 </it>gene mediate leukemogenesis, at least in part, through activation of PI3K/AKT. The mammalian target of rapamycin (mTOR)-Raptor signaling pathway is known to act downstream of AKT. Here we show that the mTOR ef...

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Main Authors: Panayiotidis Panayiotis, Patsouris Efstratios, Staikou-Drakopoulou Efi, Leventaki Vasiliki, Li Jiang, Schlette Ellen J, Grammatikakis Ioannis, Drakos Elias, Chen Weina, Medeiros L Jeffrey, Rassidakis George Z
Format: Article
Language:English
Published: BMC 2010-11-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/9/1/292

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http://www.molecular-cancer.com/content/9/1/292

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