Synthesis and in vitro bioactivity study of new hydrazide-hydrazones of 5-bromo-2-iodobenzoic acid

Synthesis and in vitro bioactivity study of new hydrazide-hydrazones of 5-bromo-2-iodobenzoic acid

In this study 14 novel hydrazide-hydrazones of 5-bromo-2-iodobenzoic acid (3-16) were synthesized on the basis of condensation reaction. The chemical structure of obtained derivatives was established on the basis of spectral data (1H NMR and 13C NMR) and the lipophilicity of synthesized molecules wa...

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Bibliographic Details
Main Authors: Łukasz Popiołek, Paweł Patrejko, Monika Gawrońska-Grzywacz, Anna Biernasiuk, Anna Berecka-Rycerz, Dorota Natorska-Chomicka, Iwona Piątkowska-Chmiel, Anna Gumieniczek, Jarosław Dudka, Monika Wujec
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Hydrazide-hydrazone
Antiproliferative activity
Antimicrobial activity
MTT assay
COX-2
769-P cell line
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220307198

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http://www.sciencedirect.com/science/article/pii/S0753332220307198

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