Design of Poly(lactic-<i>co</i>-glycolic Acid) (PLGA) Nanoparticles for Vaginal Co-Delivery of Griffithsin and Dapivirine and Their Synergistic Effect for HIV Prophylaxis

Design of Poly(lactic-<i>co</i>-glycolic Acid) (PLGA) Nanoparticles for Vaginal Co-Delivery of Griffithsin and Dapivirine and Their Synergistic Effect for HIV Prophylaxis

Long-acting topical products for pre-exposure prophylaxis (PrEP) that combine antiretrovirals (ARVs) inhibiting initial stages of infection are highly promising for prevention of HIV sexual transmission. We fabricated core-shell poly(lactide-<i>co</i>-glycolide) (PLGA) nanoparticles, loa...

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Bibliographic Details
Main Authors: Haitao Yang, Jing Li, Sravan Kumar Patel, Kenneth E. Palmer, Brid Devlin, Lisa C. Rohan
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Pharmaceutics
Subjects:
microbicides
HIV
combination ARVs
sustained release
synergism
PLGA nanoparticles
co-delivery
Online Access:https://www.mdpi.com/1999-4923/11/4/184

Internet

https://www.mdpi.com/1999-4923/11/4/184

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