Efficient Transdermal Delivery of Alendronate, a Nitrogen-Containing Bisphosphonate, Using Tip-Loaded Self-Dissolving Microneedle Arrays for the Treatment of Osteoporosis

Efficient Transdermal Delivery of Alendronate, a Nitrogen-Containing Bisphosphonate, Using Tip-Loaded Self-Dissolving Microneedle Arrays for the Treatment of Osteoporosis

To improve the transdermal bioavailability and safety of alendronate (ALN), a nitrogen-containing bisphosphonate, we developed self-dissolving microneedle arrays (MNs), in which ALN is loaded only at the tip portion of micron-scale needles by a dip-coating method (ALN(TIP)–MN). We observed micron-sc...

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Bibliographic Details
Main Authors: Hidemasa Katsumi, Yutaro Tanaka, Kaori Hitomi, Shu Liu, Ying-shu Quan, Fumio Kamiyama, Toshiyasu Sakane, Akira Yamamoto
Format: Article
Language:English
Published: MDPI AG 2017-08-01
Series:Pharmaceutics
Subjects:
self-dissolving microneedle arrays
dip-coating method
alendronate
transdermal absorption
skin irritation
osteoporosis
Online Access:https://www.mdpi.com/1999-4923/9/3/29

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https://www.mdpi.com/1999-4923/9/3/29

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