High-throughput sequencing of CD4+ T cell repertoire reveals disease-specific signatures in IgG4-related disease

High-throughput sequencing of CD4+ T cell repertoire reveals disease-specific signatures in IgG4-related disease

Abstract Background CD4+ T cells play critical roles in the pathogenesis of IgG4-related disease (IgG4-RD). The aim of this study was to investigate the TCR repertoire of peripheral blood CD4+ T cells in IgG4-RD. Methods The peripheral blood was collected from six healthy controls and eight IgG4-RD...

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Bibliographic Details
Main Authors: Liwen Wang, Panpan Zhang, Jieqiong Li, Hui Lu, Linyi Peng, Jing Ling, Xuan Zhang, Xiaofeng Zeng, Yan Zhao, Wen Zhang
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Arthritis Research & Therapy
Subjects:
IgG4-related disease
CD4+ T cells
TCR repertoire
Complementarity determining region 3
Antigen
Online Access:https://doi.org/10.1186/s13075-019-2069-6

Internet

https://doi.org/10.1186/s13075-019-2069-6

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