Syndecan-4–/– Mice Have Smaller Muscle Fibers, Increased Akt/mTOR/S6K1 and Notch/HES-1 Pathways, and Alterations in Extracellular Matrix Components

Syndecan-4–/– Mice Have Smaller Muscle Fibers, Increased Akt/mTOR/S6K1 and Notch/HES-1 Pathways, and Alterations in Extracellular Matrix Components

BackgroundExtracellular matrix (ECM) remodeling is essential for skeletal muscle development and adaption in response to environmental cues such as exercise and injury. The cell surface proteoglycan syndecan-4 has been reported to be essential for muscle differentiation, but few molecular mechanisms...

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Bibliographic Details
Main Authors: Sissel Beate Rønning, Cathrine Rein Carlson, Jan Magnus Aronsen, Addolorata Pisconti, Vibeke Høst, Marianne Lunde, Kristian Hovde Liland, Ivar Sjaastad, Svein Olav Kolset, Geir Christensen, Mona Elisabeth Pedersen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
skeletal muscle
syndecan
exercise
myogenesis
Notch
decorin
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00730/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00730/full

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