Alzheimer’s disease tau is a prominent pathology in LRRK2 Parkinson’s disease

Alzheimer’s disease tau is a prominent pathology in LRRK2 Parkinson’s disease

Abstract Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson’s disease (PD). While the clinical presentation of LRRK2 mutation carriers is similar to that of idiopathic PD (iPD) patients, the neuropathology of LRRK2 PD is less clearly defined. Lewy bodie...

Full description

Bibliographic Details
Main Authors: Michael X. Henderson, Medha Sengupta, John Q. Trojanowski, Virginia M. Y. Lee
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Acta Neuropathologica Communications
Subjects:
Leucine-rich repeat kinase 2
Aggregation
G2019S
Progressive supranuclear palsy
α-Synuclein
Amyloid β
Online Access:http://link.springer.com/article/10.1186/s40478-019-0836-x

Internet

http://link.springer.com/article/10.1186/s40478-019-0836-x

Similar Items