Propionic Acid Rescues High-Fat Diet Enhanced Immunopathology in Autoimmunity via Effects on Th17 Responses

Propionic Acid Rescues High-Fat Diet Enhanced Immunopathology in Autoimmunity via Effects on Th17 Responses

High-fat diets (HFD) are linked to obesity and associated comorbidities and induce pathogenic T helper (Th) 17 cells while decreasing regulatory T cells (Treg). This pro-inflammatory environment also aggravates immunopathology in experimental autoimmune encephalomyelitis (EAE) as a prototype model o...

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Bibliographic Details
Main Authors: Stefanie Haase, Jonas Mäurer, Alexander Duscha, De-Hyung Lee, Andras Balogh, Ralf Gold, Dominik N. Müller, Aiden Haghikia, Ralf A. Linker
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
high-fat diet
EAE
propionic acid
immunosuppression
multiple sclerosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.701626/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.701626/full

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