Modeling epistasis in mice and yeast using the proportion of two or more distinct genetic backgrounds: Evidence for "polygenic epistasis".

Modeling epistasis in mice and yeast using the proportion of two or more distinct genetic backgrounds: Evidence for "polygenic epistasis".

<h4>Background</h4>The majority of quantitative genetic models used to map complex traits assume that alleles have similar effects across all individuals. Significant evidence suggests, however, that epistatic interactions modulate the impact of many alleles. Nevertheless, identifying ep...

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Bibliographic Details
Main Authors: Christoph D Rau, Natalia M Gonzales, Joshua S Bloom, Danny Park, Julien Ayroles, Abraham A Palmer, Aldons J Lusis, Noah Zaitlen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-10-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1009165

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https://doi.org/10.1371/journal.pgen.1009165

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