Ouabain-Induced Gene Expression Changes in Human iPSC-Derived Neuron Culture Expressing Dopamine and cAMP-Regulated Phosphoprotein 32 and GABA Receptors

Ouabain-Induced Gene Expression Changes in Human iPSC-Derived Neuron Culture Expressing Dopamine and cAMP-Regulated Phosphoprotein 32 and GABA Receptors

Cardiotonic steroids (CTS) are specific inhibitors and endogenous ligands of a key enzyme in the CNS—the Na<sup>+</sup>, K<sup>+</sup>-ATPase, which maintains and creates an ion gradient on the plasma membrane of neurons. CTS cause the activation of various signaling cascades...

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Bibliographic Details
Main Authors: Alexander V. Lopachev, Maria A. Lagarkova, Olga S. Lebedeva, Margarita A. Ezhova, Rogneda B. Kazanskaya, Yulia A. Timoshina, Anastasiya V. Khutorova, Evgeny E. Akkuratov, Tatiana N. Fedorova, Raul R. Gainetdinov
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Brain Sciences
Subjects:
dopamine
GABA
RNA-seq
iPSC
cardiotonic steroids
gene expression
Online Access:https://www.mdpi.com/2076-3425/11/2/203

Internet

https://www.mdpi.com/2076-3425/11/2/203

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