Genetic Variations in the TP53 Pathway in Native Americans Strongly Suggest Adaptation to the High Altitudes of the Andes.

Genetic Variations in the TP53 Pathway in Native Americans Strongly Suggest Adaptation to the High Altitudes of the Andes.

The diversity of the five single nucleotide polymorphisms located in genes of the TP53 pathway (TP53, rs1042522; MDM2, rs2279744; MDM4, rs1563828; USP7, rs1529916; and LIF, rs929271) were studied in a total of 282 individuals belonging to Quechua, Aymara, Chivay, Cabanaconde, Yanke, Taquile, Amantan...

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Bibliographic Details
Main Authors: Vanessa Cristina Jacovas, Diego Luiz Rovaris, Orlando Peréz, Soledad de Azevedo, Gabriel Souza Macedo, José Raul Sandoval, Alberto Salazar-Granara, Mercedes Villena, Jean-Michel Dugoujon, Rafael Bisso-Machado, Maria Luiza Petzl-Erler, Francisco Mauro Salzano, Patricia Ashton-Prolla, Virginia Ramallo, Maria Cátira Bortolini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4575214?pdf=render

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http://europepmc.org/articles/PMC4575214?pdf=render

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