A common antigenic motif recognized by naturally occurring human VH5–51/VL4–1 anti-tau antibodies with distinct functionalities

A common antigenic motif recognized by naturally occurring human VH5–51/VL4–1 anti-tau antibodies with distinct functionalities

Abstract Misfolding and aggregation of tau protein are closely associated with the onset and progression of Alzheimer’s Disease (AD). By interrogating IgG+ memory B cells from asymptomatic donors with tau peptides, we have identified two somatically mutated VH5–51/VL4–1 antibodies. One of these, CBT...

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Bibliographic Details
Main Authors: Adrian Apetri, Rosa Crespo, Jarek Juraszek, Gabriel Pascual, Roosmarijn Janson, Xueyong Zhu, Heng Zhang, Elissa Keogh, Trevin Holland, Jay Wadia, Hanneke Verveen, Berdien Siregar, Michael Mrosek, Renske Taggenbrock, Jeroenvan Ameijde, Hanna Inganäs, Margot van Winsen, Martin H. Koldijk, David Zuijdgeest, Marianne Borgers, Koen Dockx, Esther J. M. Stoop, Wenli Yu, Els C. Brinkman-van der Linden, Kimberley Ummenthum, Kristof van Kolen, Marc Mercken, Stefan Steinbacher, Donata de Marco, Jeroen J. Hoozemans, Ian A. Wilson, Wouter Koudstaal, Jaap Goudsmit
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s disease
Tau protein
Monoclonal antibody
Antigenic motif
Online Access:http://link.springer.com/article/10.1186/s40478-018-0543-z

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http://link.springer.com/article/10.1186/s40478-018-0543-z

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