1-O-Tigloyl-1-O-deacetyl-nimbolinin B Inhibits LPS-Stimulated Inflammatory Responses by Suppressing NF-κB and JNK Activation in Microglia Cells

Abstract.: Overactivation of microglia may contribute to the pathogenesis of neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, and HIV dementia. Thus, regulating microglial activation has been an important therapeutic strategy for treating neurodegenerative diseases. In th...

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Bibliographic Details
Main Authors: Li Tao, Fali Zhang, Lili Hao, Jing Wu, Jia Jia, Jiang-yun Liu, Long Tai Zheng, Xuechu Zhen
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319301069