A strategy to improve phasing of whole-genome sequenced individuals through integration of familial information from dense genotype panels

A strategy to improve phasing of whole-genome sequenced individuals through integration of familial information from dense genotype panels

Abstract Background Haplotype reconstruction (phasing) is an essential step in many applications, including imputation and genomic selection. The best phasing methods rely on both familial and linkage disequilibrium (LD) information. With whole-genome sequence (WGS) data, relatively small samples of...

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Bibliographic Details
Main Authors: Pierre Faux, Tom Druet
Format: Article
Language:deu
Published: BMC 2017-05-01
Series:Genetics Selection Evolution
Subjects:
Linkage Disequilibrium
Genomic Selection
Imputation Accuracy
Single Nucleotide Polymorphism Allele
Haplotype Reconstruction
Online Access:http://link.springer.com/article/10.1186/s12711-017-0321-6

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http://link.springer.com/article/10.1186/s12711-017-0321-6

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