Feeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signalling
Time of day influences immune responses and lethality in response to LPS, with survival greatest at the beginning compared to the end of the light cycle. Here the authors show that feeding, rather than light, controls time-of-day dependent LPS sensitivity through the liver clock and hepatic FXR sign...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-05-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22961-z |