Effect of MMP-2 gene silencing on radiation-induced DNA damage in human normal dermal fibroblasts and breast cancer cells

Effect of MMP-2 gene silencing on radiation-induced DNA damage in human normal dermal fibroblasts and breast cancer cells

Abstract Introduction Diagnostic and therapeutic ionizing radiation (IR) is one of the well known long term risk factors of breast cancer. Extremely lethal consequences of IR causes double-strand breaks, which are mainly responsible for genomic instability, altered gene expression, and cell death. F...

Full description

Bibliographic Details
Main Authors: Gugalavath Shailender, Seema Kumari, Patnala Kiranmayi, Rama Rao Malla
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Genes and Environment
Subjects:
Ionizing radiation
Matrix metalloproteinase
DNA damage
Breast cancer
Fibroblasts
Online Access:http://link.springer.com/article/10.1186/s41021-019-0131-x

Internet

http://link.springer.com/article/10.1186/s41021-019-0131-x

Similar Items