Cyclophilin D is involved in the regulation of autophagy and affects the lifespan of P. anserina in response to mitochondrial oxidative stress
The mitochondrial permeability transition pore plays a key role in programmed cell death and the induction of autophagy. Opening of the mPTP is regulated by the mitochondrial peptidyl prolyl-cis,trans-isomerase cyclophilin D (CYPD). Previously it was shown in the aging model organism Podospora anser...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2016-09-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00165/full |