Regionally distinct responses of microglia and glial progenitor cells to whole brain irradiation in adult and aging rats.

Radiation therapy has proven efficacy for treating brain tumors and metastases. Higher doses and larger treatment fields increase the probability of eliminating neoplasms and preventing reoccurrence, but dose and field are limited by damage to normal tissues. Normal tissue injury is greatest during...

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Bibliographic Details
Main Authors: Kun Hua, Matthew K Schindler, Joseph A McQuail, M Elizabeth Forbes, David R Riddle
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3530502?pdf=render