Mitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expression

Mitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expression

Mutations of the PTEN-induced kinase 1 (PINK1) gene are a cause of autosomal recessive Parkinson's disease (PD). This gene encodes a mitochondrial serine/threonine kinase, which is partly localized to mitochondria, and has been shown to play a role in protecting neuronal cells from oxidative st...

Full description

Bibliographic Details
Main Authors: Rubén Gómez-Sánchez, Matthew E. Gegg, José M. Bravo-San Pedro, Mireia Niso-Santano, Lydia Alvarez-Erviti, Elisa Pizarro-Estrella, Yolanda Gutiérrez-Martín, Alberto Alvarez-Barrientos, José M. Fuentes, Rosa Ana González-Polo, Anthony H.V. Schapira
Format: Article
Language:English
Published: Elsevier 2014-02-01
Series:Neurobiology of Disease
Subjects:
SH-SY5Y
CCCP
Parkinson's disease
PINK1
Calcium
Mitophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113002969

Internet

http://www.sciencedirect.com/science/article/pii/S0969996113002969

Similar Items