A nucleoside anticancer drug, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine (TAS106), sensitizes cells to radiation by suppressing BRCA2 expression

A nucleoside anticancer drug, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine (TAS106), sensitizes cells to radiation by suppressing BRCA2 expression

<p>Abstract</p> <p>Background</p> <p>A novel anticancer drug 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine (ECyd, TAS106) has been shown to radiosensitize tumor cells and to improve the therapeutic efficiency of X-irradiation. However, the effect of TAS106 on cellular...

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Bibliographic Details
Main Authors: Fukushima Masakazu, Morimatsu Masami, Matsuda Akira, Eitaki Masato, Yasui Hironobu, Yamamori Tohru, Meike Shunsuke, Yamasaki Yasundo, Inanami Osamu
Format: Article
Language:English
Published: BMC 2011-07-01
Series:Molecular Cancer
Subjects:
radiation
DNA repair
homologous recombination
Online Access:http://www.molecular-cancer.com/content/10/1/92

Internet

http://www.molecular-cancer.com/content/10/1/92

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