Dynamic recognition and linkage specificity in K63 di-ubiquitin and TAB2 NZF domain complex

Dynamic recognition and linkage specificity in K63 di-ubiquitin and TAB2 NZF domain complex

Abstract Poly-ubiquitin (poly-Ub) is involved in various cellular processes through the linkage-specific recognition of Ub-binding domains (UBD). In this study, using molecular dynamics (MD) simulation together with an enhanced sampling method, we demonstrated that K63-linked di-Ub recognizes the NZ...

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Bibliographic Details
Main Authors: Kei Moritsugu, Hafumi Nishi, Keiichi Inariyama, Masanori Kobayashi, Akinori Kidera
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Scientific Reports
Subjects:
TAK1-binding Protein (TAB2)
Linkage Specificity
Dynamic Recognition
Ub-binding Domains (UBD)
Transforming Growth Factor Β-activated Kinase (TAK1)
Online Access:https://doi.org/10.1038/s41598-018-34605-2

Internet

https://doi.org/10.1038/s41598-018-34605-2

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