Valproic Acid Regulates HR and Cell Cycle Through MUS81-pRPA2 Pathway in Response to Hydroxyurea

Valproic Acid Regulates HR and Cell Cycle Through MUS81-pRPA2 Pathway in Response to Hydroxyurea

Breast cancer is the primary problem threatening women’s health. The combined application of valproic acid (VPA) and hydroxyurea (HU) has a synergistic effect on killing breast cancer cells, but the molecular mechanism remains elusive. Replication protein A2 phosphorylation (pRPA2), is essential for...

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Bibliographic Details
Main Authors: Benyu Su, David Lim, Zhujun Tian, Guochao Liu, Chenxia Ding, Zuchao Cai, Chen Chen, Fengmei Zhang, Zhihui Feng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Oncology
Subjects:
breast cancer
VPA
HU
pRPA2
MUS81
cell cycle
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.681278/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.681278/full

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