Dexmedetomidine Protects Mouse Brain from Ischemia-Reperfusion Injury via Inhibiting Neuronal Autophagy through Up-Regulating HIF-1α

Dexmedetomidine Protects Mouse Brain from Ischemia-Reperfusion Injury via Inhibiting Neuronal Autophagy through Up-Regulating HIF-1α

Stroke is the leading cause of death in China and produces a heavy socio-economic burden in the past decades. Previous studies have shown that dexmedetomidine (DEX) is neuroprotective after cerebral ischemia. However, the role of autophagy during DEX-mediated neuroprotection after cerebral ischemia...

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Bibliographic Details
Main Authors: Cong Luo, Ming-Wen Ouyang, Ying-Ying Fang, Shu-Ji Li, Quan Zhou, Jun Fan, Zai-Sheng Qin, Tao Tao
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
dexmedetomidine
cerebral ischemia
neuroprotection
autophagy
HIF-1α
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00197/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2017.00197/full

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