FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence

FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence

Evidence for mitotic decline in aged cells and for aneuploidy-driven progression into full senescence is limited. Here, the authors find that in aged cells, mitotic gene repression leads to increased chromosome mis-segregation and aneuploidy that triggers permanent cell cycle arrest and full senesce...

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Bibliographic Details
Main Authors: Joana Catarina Macedo, Sara Vaz, Bjorn Bakker, Rui Ribeiro, Petra Lammigje Bakker, Jose Miguel Escandell, Miguel Godinho Ferreira, René Medema, Floris Foijer, Elsa Logarinho
Format: Article
Language:English
Published: Nature Publishing Group 2018-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05258-6

Internet

https://doi.org/10.1038/s41467-018-05258-6

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