Neural and synaptic defects in slytherin, a zebrafish model for human congenital disorders of glycosylation.

Neural and synaptic defects in slytherin, a zebrafish model for human congenital disorders of glycosylation.

Congenital disorder of glycosylation type IIc (CDG IIc) is characterized by mental retardation, slowed growth and severe immunodeficiency, attributed to the lack of fucosylated glycoproteins. While impaired Notch signaling has been implicated in some aspects of CDG IIc pathogenesis, the molecular an...

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Bibliographic Details
Main Authors: Yuanquan Song, Jason R Willer, Paul C Scherer, Jessica A Panzer, Amy Kugath, Emmanuel Skordalakes, Ronald G Gregg, Gregory B Willer, Rita J Balice-Gordon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2966427?pdf=render

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http://europepmc.org/articles/PMC2966427?pdf=render

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