Transcriptomic Profiling and H3K27me3 Distribution Reveal Both Demethylase-Dependent and Independent Regulation of Developmental Gene Transcription in Cell Differentiation.

Transcriptomic Profiling and H3K27me3 Distribution Reveal Both Demethylase-Dependent and Independent Regulation of Developmental Gene Transcription in Cell Differentiation.

The removal of histone H3 trimethylation at lysine residue 27 (H3K27me3) plays a critical role in the transcriptional initiation of developmental genes. The H3K27me3-specific KDM6 demethylases JMJD3 and UTX are responsible for the transcriptional initiation of various developmental genes, but some g...

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Bibliographic Details
Main Authors: Sung Chul Kang, Se Kye Kim, Jin Choul Chai, Sun Hwa Kim, Kyoung-Jae Won, Young Seek Lee, Kyoung Hwa Jung, Young Gyu Chai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4532468?pdf=render

Internet

http://europepmc.org/articles/PMC4532468?pdf=render

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