Ablation of GSDMD Improves Outcome of Ischemic Stroke Through Blocking Canonical and Non-canonical Inflammasomes Dependent Pyroptosis in Microglia

Ablation of GSDMD Improves Outcome of Ischemic Stroke Through Blocking Canonical and Non-canonical Inflammasomes Dependent Pyroptosis in Microglia

Ischemia/reperfusion (I/R) injury is a significant cause of mortality and long-term disability worldwide. Recent evidence has proved that pyroptosis, a novel cell death form, contributes to inflammation-induced neuron death and neurological function impairment following ischemic stroke. Gasdermin D...

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Bibliographic Details
Main Authors: Kankai Wang, Zhezhe Sun, Junnan Ru, Simin Wang, Lijie Huang, Linhui Ruan, Xiao Lin, Kunlin Jin, Qichuan Zhuge, Su Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Neurology
Subjects:
ischemia/reperfusion injury
pyroptosis
neuroinflammation
gasdermin D
microglia
neurological outcome
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2020.577927/full

Internet

https://www.frontiersin.org/articles/10.3389/fneur.2020.577927/full

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