The exocyst protein Sec10 interacts with Polycystin-2 and knockdown causes PKD-phenotypes.

The exocyst protein Sec10 interacts with Polycystin-2 and knockdown causes PKD-phenotypes.

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by formation of renal cysts that destroy the kidney. Mutations in PKD1 and PKD2, encoding polycystins-1 and -2, cause ADPKD. Polycystins are thought to function in primary cilia, but it is not well understood how these and other p...

Full description

Bibliographic Details
Main Authors: Ben Fogelgren, Shin-Yi Lin, Xiaofeng Zuo, Kimberly M Jaffe, Kwon Moo Park, Ryan J Reichert, P Darwin Bell, Rebecca D Burdine, Joshua H Lipschutz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3072367?pdf=render

Internet

http://europepmc.org/articles/PMC3072367?pdf=render

Similar Items