Phosphorylation of eIF2α signaling pathway attenuates obesity-induced non-alcoholic fatty liver disease in an ER stress and autophagy-dependent manner

Phosphorylation of eIF2α signaling pathway attenuates obesity-induced non-alcoholic fatty liver disease in an ER stress and autophagy-dependent manner

Abstract Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder and frequently exacerbates in postmenopausal women. In NAFLD, the endoplasmic reticulum (ER) plays an important role in lipid metabolism, in which salubrinal is a selective inhibitor of eIF2α de-phosphorylation in r...

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Bibliographic Details
Main Authors: Jie Li, Xinle Li, Daquan Liu, Shiqi Zhang, Nian Tan, Hiroki Yokota, Ping Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-020-03264-5

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https://doi.org/10.1038/s41419-020-03264-5

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