Inhibition of Wnt signaling pathway suppresses radiation-induced dermal fibrosis

Abstract Progressive fibrosis of the dermal tissues is a challenging complication of radiotherapy whose underlying mechanism is not fully understood, and there are few available treatments. The canonical Wnt/β-catenin signaling pathway plays an important role in fibrosis as well as in the epithelial...

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Bibliographic Details
Main Authors: Dong Won Lee, Won Jai Lee, Jaeho Cho, Chae-Ok Yun, Hyun Roh, Hsien Pin Chang, Tai Suk Roh, Ju Hee Lee, Dae Hyun Lew
Format: Article
Language:English
Published: Nature Publishing Group 2020-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-70243-3