Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase

Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase

Summary: A hallmark of type 2 diabetes (T2D) is hepatic resistance to insulin’s glucose-lowering effects. The serum- and glucocorticoid-regulated family of protein kinases (SGK) is activated downstream of mechanistic target of rapamycin complex 2 (mTORC2) in response to insulin in parallel to AKT. S...

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Bibliographic Details
Main Authors: Ben Zhou, Yuyao Zhang, Sainan Li, Lianfeng Wu, Geza Fejes-Toth, Aniko Naray-Fejes-Toth, Alexander A. Soukas
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Cell Reports
Subjects:
mTORC2
SGK
AMPK
mTORC1
hepatic insulin resistance
type 2 diabetes
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721012444

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http://www.sciencedirect.com/science/article/pii/S2211124721012444

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