FoxM1 Promotes Stemness and Radio-Resistance of Glioblastoma by Regulating the Master Stem Cell Regulator Sox2.

FoxM1 Promotes Stemness and Radio-Resistance of Glioblastoma by Regulating the Master Stem Cell Regulator Sox2.

Glioblastoma (GBM) is the most aggressive and most lethal brain tumor. As current standard therapy consisting of surgery and chemo-irradiation provides limited benefit for GBM patients, novel therapeutic options are urgently required. Forkhead box M1 (FoxM1) transcription factor is an oncogenic regu...

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Bibliographic Details
Main Authors: Yeri Lee, Kang Ho Kim, Dong Geon Kim, Hee Jin Cho, Yeonghwan Kim, Jinguen Rheey, Kayoung Shin, Yun Jee Seo, Yeon-Sook Choi, Jung-Il Lee, Jeongwu Lee, Kyeung Min Joo, Do-Hyun Nam
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4596841?pdf=render

Internet

http://europepmc.org/articles/PMC4596841?pdf=render

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