Large-Scale Simulation of the Phenotypical Variability Induced by Loss-of-Function Long QT Mutations in Human Induced Pluripotent Stem Cell Cardiomyocytes

Large-Scale Simulation of the Phenotypical Variability Induced by Loss-of-Function Long QT Mutations in Human Induced Pluripotent Stem Cell Cardiomyocytes

Loss-of-function long QT (LQT) mutations inducing LQT1 and LQT2 syndromes have been successfully translated to human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) used as disease-specific models. However, their in vitro investigation mainly relies on experiments using small number...

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Bibliographic Details
Main Authors: Michelangelo Paci, Simona Casini, Milena Bellin, Jari Hyttinen, Stefano Severi
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:International Journal of Molecular Sciences
Subjects:
action potential
disease model
induced pluripotent stem cell-derived cardiomyocyte
in silico drug tests
in silico model
long QT
<i>population of models</i>
Online Access:https://www.mdpi.com/1422-0067/19/11/3583

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https://www.mdpi.com/1422-0067/19/11/3583

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