Cytoskeleton reorganization as an alternative mechanism of store-operated calcium entry control in neuroendocrine-differentiated cells.

Neuroendocrine differentiation (NED) is a hallmark of advanced androgen-independent prostate cancer, for which no successful therapy exists. NED tumour cells escape apoptotic cell death by alterations of Ca(2+) homeostasis where the store-operated Ca(2+) entry (SOCE) is known to be a key event. We h...

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Bibliographic Details
Main Authors: Karine Vanoverberghe, V'yacheslav Lehen'kyi, Stéphanie Thébault, Maylis Raphaël, Fabien Vanden Abeele, Christian Slomianny, Pascal Mariot, Natalia Prevarskaya
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3458093?pdf=render