Salinomycin induces cell death and differentiation in head and neck squamous cell carcinoma stem cells despite activation of epithelial-mesenchymal transition and Akt

Salinomycin induces cell death and differentiation in head and neck squamous cell carcinoma stem cells despite activation of epithelial-mesenchymal transition and Akt

<p>Abstract</p> <p>Background</p> <p>Cancer stem cells (CSC) are believed to play a crucial role in cancer recurrence due to their resistance to conventional chemotherapy and capacity for self-renewal. Recent studies have reported that salinomycin, a livestock antibioti...

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Bibliographic Details
Main Authors: Kuo Selena Z, Blair Katherine J, Rahimy Elham, Kiang Alan, Abhold Eric, Fan Jian-Bing, Wang-Rodriguez Jessica, Altuna Xabier, Ongkeko Weg M
Format: Article
Language:English
Published: BMC 2012-11-01
Series:BMC Cancer
Subjects:
Salinomycin
Cancer stem cells
Head and neck squamous cell carcinoma
Akt
EMT
microRNA
Online Access:http://www.biomedcentral.com/1471-2407/12/556

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http://www.biomedcentral.com/1471-2407/12/556

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