THE TSH RECEPTOR GLO ASSAY -A HIGH THROUGHPUT DETECTION SYSTEM FOR THYROID STIMULATION

THE TSH RECEPTOR GLO ASSAY -A HIGH THROUGHPUT DETECTION SYSTEM FOR THYROID STIMULATION

Background: To identify novel small molecules against the TSH receptor, we developed a sensitive transcription-based luciferase high-throughput screening (HTS) system named the TSHR-Glo Assay (TSHR-Glo). Methods: This assay uses double-transfected CHO cells stably expressing the human TSHR and a cAM...

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Bibliographic Details
Main Authors: Rauf eLatif, Zerlina eLau, Pamela eCheung, Dan P Felsenfeld, Terry Francis Davies
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-01-01
Series:Frontiers in Endocrinology
Subjects:
screening
small molecule
high-throughput
TSH receptor
thyroid stimulating hormone.
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2016.00003/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fendo.2016.00003/full

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