E2F-dependent transcription determines replication capacity and S phase length
DNA replication is tightly regulated during S phase of the cell cycle to ensure timely and accurate genome duplication. Here, the authors reveal that E2F-dependent transcription determines the maximal amount of DNA a cell is able to synthesise per unit time throughout S phase.
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2020-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-17146-z |