Clinical Epigenetic Therapies Disrupt Sex Chromosome Dosage Compensation in Human Female Cells
Sex chromosome gene dosage compensation is required to ensure equivalent levels of X-linked gene expression between males (46, XY) and females (46, XX). To achieve similar expression, X-chromosome inactivation (XCI) is initiated in female cells during early stages of embryogenesis. Within each cell,...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2018-01-01
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| Series: | Gender and the Genome |
| Online Access: | https://doi.org/10.1177/2470289718787106 |