Post-Translational Modifications Modulate Proteinopathies of TDP-43, FUS and hnRNP-A/B in Amyotrophic Lateral Sclerosis

Post-Translational Modifications Modulate Proteinopathies of TDP-43, FUS and hnRNP-A/B in Amyotrophic Lateral Sclerosis

It has been shown that protein low-sequence complexity domains (LCDs) induce liquid-liquid phase separation (LLPS), which is responsible for the formation of membrane-less organelles including P-granules, stress granules and Cajal bodies. Proteins harbouring LCDs are widely represented among RNA bin...

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Bibliographic Details
Main Authors: Stefania Farina, Francesca Esposito, Martina Battistoni, Giuseppe Biamonti, Sofia Francia
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Molecular Biosciences
Subjects:
post-translational modifications
RNA binding proteins
low-complexity domain
protein aggregations
amyotrophic lateral sclerosis
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.693325/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.693325/full

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