Molecular Informatics Studies of the Iron-Dependent Regulator (ideR) Reveal Potential Novel Anti-<i>Mycobacterium ulcerans</i> Natural Product-Derived Compounds

Molecular Informatics Studies of the Iron-Dependent Regulator (ideR) Reveal Potential Novel Anti-<i>Mycobacterium ulcerans</i> Natural Product-Derived Compounds

Buruli ulcer is a neglected tropical disease caused by the bacterium <i>Mycobacterium ulcerans.</i> Its virulence is attributed to the dermo-necrotic polyketide toxin mycolactone, whose synthesis is regressed when its iron acquisition system regulated by the iron-dependent regulator (ide...

Full description

Bibliographic Details
Main Authors: Samuel K. Kwofie, Kweku S. Enninful, Jaleel A. Yussif, Lina A. Asante, Mavis Adjei, Kwabena Kan-Dapaah, Elvis K. Tiburu, Wilhelmina A. Mensah, Whelton A. Miller, Lydia Mosi, Michael D. Wilson
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Molecules
Subjects:
buruli ulcer
<i>Mycobacterium ulcerans</i>
iron dependent regulator (ideR)
metal binding site
DNA–binding site
natural product compounds
molecular docking
molecular dynamics simulation
Online Access:https://www.mdpi.com/1420-3049/24/12/2299

Internet

https://www.mdpi.com/1420-3049/24/12/2299

Similar Items