Hedgehog inhibitors in rhabdomyosarcoma: a comparison of 4 compounds and responsiveness of 4 cell lines

Hedgehog inhibitors in rhabdomyosarcoma: a comparison of 4 compounds and responsiveness of 4 cell lines

Rhabdomyosarcoma (RMS) are the most common soft tissue sarcoma in children and are divided into two major histological subgroups, i.e. embryonal (ERMS) and alveolar RMS (ARMS). RMS can show HEDGEHOG/SMOOTHENED (HH/SMO) signaling activity and several clinical trials using HH inhibitors for therapy of...

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Bibliographic Details
Main Authors: Rosalie eRidzewski, Diana eRettberg, Kai eDittmann, Nicole eCuvelier, Simone eFulda, Heidi eHahn
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-06-01
Series:Frontiers in Oncology
Subjects:
Rhabdomyosarcoma
HHA
GDC-0449
LDE225
Cyclopamine
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00130/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00130/full

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