Possible Role of NADPH Oxidase 4 in Angiotensin II-Induced Muscle Wasting in Mice

Possible Role of NADPH Oxidase 4 in Angiotensin II-Induced Muscle Wasting in Mice

Background: Muscle wasting is a debilitating phenotype associated with chronic heart failure (CHF). We have previously demonstrated that angiotensin II (AII) directly induces muscle wasting in mice through the activation of NADPH oxidase (Nox). In this study, we tested the hypothesis that deficiency...

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Bibliographic Details
Main Authors: Tomoyasu Kadoguchi, Kazunori Shimada, Hiroshi Koide, Tetsuro Miyazaki, Tomoyuki Shiozawa, Shuhei Takahashi, Tatsuro Aikawa, Shohei Ouchi, Kenichi Kitamura, Yurina Sugita, Al Shahi Hamad, Mitsuhiro Kunimoto, Yayoi Sato-Okabayashi, Koji Akita, Kikuo Isoda, Hiroyuki Daida
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Physiology
Subjects:
angiotensin II
muscle atrophy
oxidative stress
NADPH oxidase 4
Nrf2 signaling
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2018.00340/full

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http://journal.frontiersin.org/article/10.3389/fphys.2018.00340/full

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