A General Synthesis of Bis-indolylpiperazine-2,5-diones

The one-pot synthesis of three dragmacidin derivatives is reported. Sarcosine anhydride (4) is brominated and immediately reacted with the corresponding indole to produce the products, namely 3,6-bis(5′-methoxy-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (1), 3,6-bis(7&a...

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Bibliographic Details
Main Authors: Christine Whitlock, Stephen Crooke
Format: Article
Language:English
Published: MDPI AG 2012-12-01
Series:Molecules
Subjects:
Online Access:http://www.mdpi.com/1420-3049/17/12/14841