Evidence for the contribution of the hemozoin synthesis pathway of the murine Plasmodium yoelii to the resistance to artemisinin-related drugs.

Evidence for the contribution of the hemozoin synthesis pathway of the murine Plasmodium yoelii to the resistance to artemisinin-related drugs.

Plasmodium falciparum malaria is a major global health problem, causing approximately 780,000 deaths each year. In response to the spreading of P. falciparum drug resistance, WHO recommended in 2001 to use artemisinin derivatives in combination with a partner drug (called ACT) as first-line treatmen...

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Bibliographic Details
Main Authors: Benoit Witkowski, Joel Lelièvre, Marie-Laure Nicolau-Travers, Xavier Iriart, Patrice Njomnang Soh, Fatima Bousejra-Elgarah, Bernard Meunier, Antoine Berry, Françoise Benoit-Vical
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3293827?pdf=render

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http://europepmc.org/articles/PMC3293827?pdf=render

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